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中华腔镜外科杂志(电子版) ›› 2020, Vol. 13 ›› Issue (05): 270 -273. doi: 10.3877/cma.j.issn.1674-6899.2020.05.004

所属专题: 经典病例 总编推荐 经典病例 文献资源库

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腹腔镜手术治疗深部浸润型子宫内膜异位症225例临床分析
李震 1, 张妮娜 1, 王铭洋 1, 张小燕 1, 叶明侠 1, 顾成磊 1, 李立安 1, 孟元光 1 , ( )   
  1. 1. 100853 北京,解放军总医院第一医学中心妇产科
  • 收稿日期:2020-08-20 出版日期:2020-10-30
  • 通信作者: 孟元光

Clinical analysis of laparoscopic deep infiltrating endometriosis surgery in 225 cases

Zhen Li 1, Nina Zhang 1, Mingyang Wang 1, Xiaoyan Zhang 1, Mingxia Ye 1, Chenglei Gu 1, Lian Li 1, Yuanguang Meng 1 , ( )   

  1. 1. Department of Obstetrics and Gynecology, Chinese PLA General Hospital, Beijing 100853, China
  • Received:2020-08-20 Published:2020-10-30
  • Corresponding author: Yuanguang Meng
  • About author:
    Corresponding author: Meng Yuanguang, Email:
目的

探讨腹腔镜手术治疗深部浸润型子宫内膜异位症(deep infiltrating endometriosis, DIE)的疗效。

方法

回顾性分析解放军总医院第一医学中心2008年1月至2018年7月共225例DIE患者,所有患者均接受彻底的腹腔镜子宫内膜异位病灶切除术并进行长期随访。统计患者的临床资料、围手术期参数、复发及自然受孕率等指标。

结果

225例患者中,178例(79.1%)患者有痛经症状,33例(14.7%)患者有性交痛,1例(0.4%)患者伴有便血,2例(0.9%)患者伴有血尿,8例(3.6%)患者伴有便秘,6例(2.7%)患者伴有腹泻,42例(18.7%)患者为无症状。平均术中出血量(94.4±191.6)ml,平均手术时间(85.5±51.0)min,平均住院时间(8.4±4.9)d 。并发症发生率:1.3%。随访时间1~144个月(中位随访时间57个月),术后24个月复发率8.4%,术后60个月复发率16.4%,至随访截止总体复发率19.6%。自然受孕率67.5%。

结论

腹腔镜手术治疗DIE疗效满意。

Objective

To discuss the efficacy of laparoscopic deep infiltrating endometriosis surgery.

Methods

Clinical data of 225 cases who underwent laparoscopic deep infiltrating endometriosis surgery in Chinese PLA General Hospital between Jan. 2008 and Jul. 2018 were analyzed retrospectively. Clinical features, perioperative outcomes, recurrence and natural conception rate were analyzed.

Results

Among the 225 cases, 178 cases(79.1%) had dysmenorrhea, 33 cases (14.7%)had dyspareunia, 1 case(0.4%) had hematochezia, 2 cases (0.9%)had hematuresis, 8 cases (3.6%)had constipation, 6 cases (2.7%)had diarrhea, 42 cases (18.7%)had no symptom. Average blood loss was(94.4±191.6) ml, average operative time was (85.5±51.0) min, average hospital stay was (8.4±4.9) d. Complication rate was 1.3%. Follow up period ranged from 1-144 months(Median follow-up time 57 months ), 24 months recurrence rate was 8.4%, 60 months recurrence rate was 16.4%, overall recurrence rate was 19.6%. Natural conception rate was 67.5%.

Conclusions

Laparoscopic deep infiltrating endometriosis surgery is safe and effective for deep infiltrating endometriosis.

图1 直肠、骶韧带深部浸润型子宫内膜异位症的手术步骤
图2 深部浸润型子宫内膜异位症患者术后复发情况生存分析
图3 游离输尿管的方法
1
中华医学会妇产科学分会子宫内膜异位症协作组.子宫内膜异位症的诊治指南[J].中华妇产科杂志,2015,50(3):161-169.
2
Collinet P, Fritel X, Revel-Delhom C, et al. Management of endometriosis: cngof/has clinical practice guidelines-short version[J]. Gynecol Obstet Fertil Senol, 2018, 47(7): 265-274.
3
Singh SS, Suen MWH.Surgery for endometriosis: beyond medical therapies[J]. Fertility & Sterility, 2017, 107(3):549-554.
4
郎景和. 对子宫内膜异位症认识的历史、现状与发展[J].中国实用妇科与产科杂志,2020, 36(3): 193-196.
5
中国医师协会妇产科医师分会子宫内膜异位症专业委员会,中华医学会妇产科学分会子宫内膜异位症协作组.子宫内膜异位症长期管理中国专家共识[J]. 中华妇产科杂志,2018, 53(12):836-841.
6
刘青,孙雨欣,刘开江,等. 输尿管子宫内膜异位症16例诊治分析[J].中国实用妇科与产科杂志,2019, 35(8): 934-937.
7
Roman H, Ballester M, Loriau J, et al. Strategies and surgical management of endometriosis: cngof-has endometriosis guidelines[J]. Gynecol Obstet Fertil Senol,2018, 46(3): 326-330.
8
Fertility J, Sterility. Treatment of pelvic pain associated with endometriosis: a committee opinion[J]. Fertil Steril, 2014, 101(4): 927-395.
9
Ballester M, Roman H. Surgical management of deep endometriosis with colorectal involvement: cngof-has endometriosis guidelines[J]. Gynecol Obstet Fertil Senol, 2018, 46(3): 290-295.
10
Carey ET, Till SR, Sanie J. Pharmacological management of chronic pelvic pain in women[J]. Drugs, 2017, 77(3): 285-301.
11
Sanie S, Kim J, Schmidt-Wilcke T, et al. Functional connectivity is associated with altered brain chemistry in women with endometriosis-associated chronic pelvic pain[J]. The journal of pain: official journal of the American Pain Society,2016, 17(1): 1-13.
12
Zondervan KT, Becker CM, Missmer SA.Endometriosis[J].N Engl J Med, 2020, 382(13): 1244-1256.
13
Centini G, Afors K, Murtada R, et al. Impact of laparoscopic surgical management of deep endometriosis on pregnancy rate[J]. J Minim Invasive Gynecol, 2016, 23(1): 113-119.
14
Knabben L, Imboden S, Fellmann B,et al. Urinary tract endometriosis inpatients with deep infiltrating endometriosis: prevalence, symptoms, management, andproposal for a new clinical classification[J]. Fertility & Sterility, 2015, 103(1):147-152.
15
Chapron C, Chiodo I, Leconte M,et al. Severe ureteral endometriosis: the intrinsic type is not so rare after complete surgical exeresis of deep endometriotic lesions[J]. Fertility & Sterility, 2010, 93(7):2115-2120.
16
Cavaco-Gomes J, Martinho M, Gilabert-Aguilar J,et al. Laparoscopic management of ureteral endometriosis: a systematic review[J]. European journal of obstetrics, gynecology, and reproductive biology, 2017, 210:94-101. DOI: 10.1016/j.ejogrb.2016.12.011
17
Roman H, Chanavaz-Lacheray I, Ballester M, et al. High postoperative fertility rate following surgical management of colorectal endometriosis[J]. Human Reproduction,2018, 33(9): 1669-1676.
18
彭超,周应芳.合并深部子宫内膜异位症的腹腔镜子宫切除经验及思考[J/CD].中华腔镜外科杂志(电子版),2020,13(2):77-80.
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