To discuss the aseptic and tumor-free skills and to investigate the short-term effects of laparoscopic natural orifice specimen extraction surgery (NOSES) for colorectal cancer by means of body-inside resection and dragging-out removal.

The clinical data of 26 patients with colorectal cancer who underwent laparoscopic NOSES operation by means of body-inside resection and dragging-out removal via rectum from Jun. 2017 to Nov. 2018 in Sichuan cancer hospital were retrospectively analyzed, including the operation duration, intraoperative bleeding, intraperitoneal contamination, postoperative exhausting time, postoperative complications, hospital stay, and status of tumor recurrence and metastasis.

All operations of 26 patients were completed successfully, with average operative time 240.4 minutes (150-330 minutes), intraoperative bleeding 56.9 ml (20-100 ml), postoperative exhausting time 21.3 hours (8-48 hours), and average hospital stay 10.0 days (7-15 days). No postoperative complications were observed, and no recurrence or metastasis has been found up to now.

Laparoscopic colorectal NOSES operation by means of body-inside resection and dragging-out removal is safe and feasible, with advantages of minimally invasion and fast recovery. As long as the principle of asepsis and tumor-free is strictly observed and the key manipulation skills are proficiently mastered, the risk of intraperitoneal contamination and iatrogenic spread of tumors can be effectively avoided.