The Hepatobiliary and Pancreatic Medical Center of People′s Hospital of Xinjiang Uygur Autonomous Region, in collaboration with the Department of Hepatopancreatobiliary Surgery of The First Medical Center of Chinese PLA General Hospital, successfully performed a 5G remote robotic-assisted hepatic hydatid cyst resection in a patient with situs inversus totalis (mirror-image person) using a robotic surgical system. The straight-line spatial distance of this remote surgery was approximately 3000 km, with a total operation duration of 150 minutes, including 110 minutes of remote control operation. The intraoperative blood loss was 50 ml, no network interruption or robot-related adverse events occurred during the entire operation, and the patient recovered smoothly and was discharged on the 6th day after surgery. This case is the world′s first remote robot-assisted hepatic hydatid cyst resection in a patient with situs inversus totalis. The successful surgery solved the problem of surgical adaptation caused by the mirrored inversion of anatomical structures in patients with situs inversus totalis, achieved precise synchronization and low-latency control of 5G remote robotic surgery, and at the same time broke the geographical barriers of medical resources, opening up a new path for remote multi-team collaborative diagnosis and treatment of special cases.