To explore the feasibility and safety of vaginal radical hysterectomy combined with transvaginal endoscopic extraperitoneal lymph node dissection(vNOTES Assisted VRH) for early-stage cervical cancer.

Retrospectively analyzed three cases with early-stage cervical cancer treated with vNOTES Assisted VRH in the Department of Gynecology, Foshan Women and Children Hospital.

Vaginal radical hysterectomy combined with transvaginal endoscopic extraperitoneal lymph node dissection was performed in two patients early-stage cervical cancer, vaginal radical trachelectomy combined with transvaginal endoscopic extraperitoneal lymph node dissection was performanced in one case. The average operative time was 246.66 minutes, including an average of 172.33 minutes for the pelvic lymph node dissection, with an average operative blood loss of 123.33 ml. There were no intraoperative complications. Postoperative pathology confirmed that the number of resected pelvic lymph nodes were 26, 21, and 14, respectively. All patients recovered anal exhaust on the second day after operation. 2 patients developed postoperative pelvic lymphatic cysts. No recurrence or death within 3 years of post-operative follow-up.

vNOTES Assisted VRH is feasible and safe for the treatment of early-stage cervical cancer, but more studies are needed to prove it.