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中华腔镜外科杂志(电子版) ›› 2024, Vol. 17 ›› Issue (06) : 380 -384. doi: 10.3877/cma.j.issn.1674-6899.2024.06.012

综述

吲哚菁绿荧光成像在子宫内膜异位症微创手术中的应用
吴佩阳1, 卢珺1, 梁炎春1,2,3,()   
  1. 1.530022 南宁,中山大学附属第一医院广西医院妇产科
    2.510700 广州,中山大学附属第一医院妇产科
    3.511356 广州,广东省妇产疾病临床医学研究中心
  • 收稿日期:2024-09-05 出版日期:2024-12-30
  • 通信作者: 梁炎春
  • 基金资助:
    国家自然科学基金项目(82071618)广东省基础与应用基础研究基金自然科学基金( 2022A1515220143、2023A1515010018)2022年度广州市基础研究计划基础与应用基础研究项目(202201011555)广东省医学科研基金(B2022069)2022年揭阳市科技创新发展专项引导项目(DZX083)2022年揭阳市卫生医疗类项目(2022wsyl016)

Application of indocyanine green fluorescence imaging in minimally invasive surgery for endometriosis

Peiyang Wu1, Jun Lu1, Yanchun Liang1,2,3,()   

  1. 1.Department of Obstetrics and Gynecology,Guangxi Hospital,The First Affiliated Hospital of Sun Yat-sen University,Nanning 530022,China
    2.Department of Obstetrics and Gynecology,The first affiliate hospital of Sun Yat-sen University,Guangzhou 510700,China
    3.Guangdong Provincial Clinical Research Center for Obstetrical and Gynecological Diseases,Guangzhou 511356,China
  • Received:2024-09-05 Published:2024-12-30
  • Corresponding author: Yanchun Liang
引用本文:

吴佩阳, 卢珺, 梁炎春. 吲哚菁绿荧光成像在子宫内膜异位症微创手术中的应用[J/OL]. 中华腔镜外科杂志(电子版), 2024, 17(06): 380-384.

Peiyang Wu, Jun Lu, Yanchun Liang. Application of indocyanine green fluorescence imaging in minimally invasive surgery for endometriosis[J/OL]. Chinese Journal of Laparoscopic Surgery(Electronic Edition), 2024, 17(06): 380-384.

子宫内膜异位症(endometriosis,EMs)是一种常见的妇科良性疾病,严重影响妇女健康。手术治疗是其中一种重要的治疗手段,但是病灶往往累及宫骶韧带、肠道、输尿管或膀胱等多个组织脏器,目前尚无精准手段可以协助手术医师安全和彻底切除病灶。 近年来,已陆续有报道称吲哚菁绿(indocyanine green,ICG)荧光成像可用于EMs 的手术治疗,协助术中识别病灶的位置以及辨认病灶切除的边界,提高手术的安全性、彻底性,减少手术相关并发症。 本综述拟对ICG 荧光成像在EMs 微创手术中的应用进行介绍,为该技术在临床推广和应用提供指导。

Endometriosis (EMs) is a common benign gynecological disease that seriously affects women′s health. Surgical treatment is one of the important treatments. But it often involves multiple tissues and organs such as the uterosacral ligament,intestine,ureter,or bladder,and there is no precise method to assist the surgeon to remove the lesion safely and completely. In recent years,it has been reported that indocyanine green (ICG) fluorescence imaging can be used in the surgical treatment of EMs,assisting in the identification of the location of the lesion and the boundary of the lesion resection during surgery,improving the safety and thoroughness of the operation,and reducing the complications related to surgery. This review aims to introduce the application of ICG fluorescence imaging in minimally invasive surgery for EMs,and provide guidance for the clinical promotion and application of this technology.

36
Spagnolo E,Hernandez A,Pascual I,et al. Bowel and ureteral assessment by indocyanine green real-time visualization during deep infiltrating endometriosis surgery -a video vignette[J]. Colorectal Dis,2020,22(10):1464-1465.
37
Raimondo D,Borghese G,Mabrouk M,et al. Use of indocyanine green for intraoperative perfusion assessment in women with ureteral endometriosis: a preliminary study[J]. J Minim Invasive Gynecol,2021,28(1):42-49.
38
Abrao M S,Petraglia F,Falcone T,et al. Deep endometriosis infiltrating the recto-sigmoid: critical factors to consider before management[J]. Hum Reprod Update,2015,21(3):329-339.
39
Darwish B,Roman H. Surgical treatment of deep infiltrating rectal endometriosis: in favor of less aggressive surgery[J]. Am J Obstet Gynecol,2016,215(2):195-200.
40
Roman H,Bridoux V,Merlot B,et al. Risk of bowel fistula following surgical management of deep endometriosis of the rectosigmoid: a series of 1102 cases[J]. Hum Reprod,2020,35(7):1601-1611.
41
Abo C,Moatassim S,Marty N,et al. Postoperative complications after bowel endometriosis surgery by shaving,disc excision,or segmental resection: a three-arm comparative analysis of 364 consecutive cases[J]. Fertil Steril,2018,109(1):172-178.
42
Keller DS,Ishizawa T,Cohen R,et al. Indocyanine green fluorescence imaging in colorectal surgery: overview,applications,and future directions[J]. Lancet Gastroenterol Hepatol,2017,2(10):757-766.
43
Gossedge G,Vallance A,Jayne D. Diverse applications for near infra-red intraoperative imaging[J]. Colorectal Dis,2015,17 Suppl 3:7-11.
44
Sutton CJ,Ewen SP,Whitelaw N,et al. Prospective,randomized,double-blind,controlled trial of laser laparoscopy in the treatment of pelvic pain associated with minimal,mild,and moderate endometriosis[J]. Fertil Steril,1994,62(4):696-700.
45
Bar-Shavit Y,Jaillet L,Chauvet P,et al. Use of indocyanine green in endometriosis surgery[J]. Fertil Steril,2018,109(6):1136-1137.
46
Seracchioli R,Raimondo D,Arena A,et al. Clinical use of endovenous indocyanine green during rectosigmoid segmental resection for endometriosis[J]. Fertil Steril,2018,109(6):1135.
47
Kim CJ,Nam HS,Lee CY,et al. Catamenial hemoptysis:a nationwide analysis in Korea[J]. Respiration,2010,79(4):296-301.
48
Son JH,Kim DH,Park JM,et al. Successful treatment of catamenial hemoptysis by single-incision thoracoscopic left S9 + 10 segmentectomy using indocyanine green injection-assisted targeting[J]. Gen Thorac Cardiovasc Surg,2021,69(3):568-571.
49
Caruso S,Iraci M,Cianci S,et al. Comparative,open-label prospective study on the quality of life and sexual function of women affected by endometriosis-associated pelvic pain on 2 mg dienogest/30 microg ethinyl estradiol continuous or 21/7 regimen oral contraceptive[J]. J Endocrinol Invest,2016,39(8):923-931.
50
Duffy JM,Arambage K,Correa FJ,et al. Laparoscopic surgery for endometriosis[ J]. Cochrane Database Syst Rev,2014 (4):D11031.
1
Kennedy S,Bergqvist A,Chapron C,et al. ESHRE guideline for the diagnosis and treatment of endometriosis[J]. Hum Reprod,2005,20(10):2698-2704.
2
Greene R,Stratton P,Cleary SD,et al. Diagnostic experience among 4,334 women reporting surgically diagnosed endometriosis[J]. Fertil Steril,2009,91(1):32-39.
3
Dunselman GA,Vermeulen N,Becker C,et al. ESHRE guideline:management of women with endometriosis[J]. Hum Reprod,2014,29(3):400-412.
4
Jansen RP,Russell P. Nonpigmented endometriosis: clinical,laparoscopic,and pathologic definition[J]. Am J Obstet Gynecol,1986,155(6):1154-1159.
5
Siegenthaler F,Knabben L,Mohr S,et al. Visualization of endometriosis with laparoscopy and near-infrared optics with indocyanine green[J]. Acta Obstet Gynecol Scand,2020,99(5):591-597.
6
Taylor E,Williams C. Surgical treatment of endometriosis: location and patterns of disease at reoperation[J]. Fertil Steril,2010,93(1):57-61.
7
Slabuszewska-Jozwiak A,Ciebiera M,Baran A,et al. Effectiveness of laparoscopic surgeries in treating infertility related to endometriosis[J]. Ann Agric Environ Med,2015,22(2):329-331.
8
Ferreira H,Smith AV,Wattiez A. Application of indocyanine green in gynecology: review of the literature[J]. Surg Technol Int,2019,34:282-292.
9
Papathemelis T,Scharl A,Anapolski M,et al. Value of indocyanine green pelvic lymph node mapping in the surgical approach of cervical cancer[J]. Arch Gynecol Obstet,2020,301(3):787-792.
10
Crane LM,Themelis G,Arts HJ,et al. Intraoperative near-infrared fluorescence imaging for sentinel lymph node detection in vulvar cancer: first clinical results[J]. Gynecol Oncol,2011,120(2):291-295.
11
Papadia A,Imboden S,Siegenthaler F,et al. Laparoscopic indocyanine green sentinel lymph node mapping in endometrial cancer[J]. Ann Surg Oncol,2016,23(7):2206-2211.
12
王酉,严斌,狄文,等. 经脐单孔腹腔镜前哨淋巴结活检术在早期子宫内膜癌手术中的探讨[J/CD]. 中华腔镜外科杂志(电子版),2024,17(3):173-176.
13
Achterberg FB,Bijlstra OD,Slooter MD,et al. ICG-fluorescence imaging for margin assessment during minimally invasive colorectal liver metastasis resection[J]. JAMA Netw Open,2024,7(4):e246548.
14
Handgraaf H,Sibinga MB,Shahbazi FS,et al. Staging laparoscopy with ultrasound and near-infrared fluorescence imaging to detect occult metastases of pancreatic and periampullary cancer[J]. PLoS One,2018,13(11):e205960.
15
Fritch C,Church E,Wilkinson DA. Advances in intraoperative imaging for vascular neurosurgery[J]. Neuroimaging clinics of North America,2024,34(2):261-270.
16
Tran AQ,Park RB,Lee DK,et al. Qualitative use of ICG angiography and lymphography in periorbital surgery[J]. Orbit,2024,43(2):196-202.
17
Tosti C,Pinzauti S,Santulli P,et al. Pathogenetic mechanisms of deep infiltrating endometriosis[J]. Reprod Sci,2015,22(9):1053-1059.
18
Machado DE,Abrao MS,Berardo PT,et al. Vascular density and distribution of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 (Flk-1) are significantly higher in patients with deeply infiltrating endometriosis affecting the rectum[J]. Fertil Steril,2008,90(1):148-155.
19
Levey KA. Use of fluorescence imaging technology to identify peritoneal endometriosis: a case report of new technology[J]. Surg Laparosc Endosc Percutan Tech,2014,24(2):e63-e65.
20
Park H,Farnam RW. Novel Use of Indocyanine Green for Intraoperative,Real-time Localization of Ureter During Robot-Assisted Excision of Endometriosis[J]. J Minim Invasive Gynecol,2015,22(6S):S69.
21
Cosentino F,Vizzielli G,Turco L C,et al. Near-infrared imaging with indocyanine green for detection of endometriosis lesions (greendo trial): a pilot study[J]. J Minim Invasive Gynecol,2018,25(7):1249-1254.
22
Guan X,Nguyen MT,Walsh TM,et al. Robotic Single-Site Endometriosis Resection Using Firefly Technology[J]. J Minim Invasive Gynecol,2016,23(1):10-11.
23
Greene R,Stratton P,Cleary SD,et al. Diagnostic experience among 4,334 women reporting surgically diagnosed endometriosis[J]. Fertil Steril,2009,91(1):32-39.
24
Ceccaroni M,Clarizia R,Bruni F,et al. Nerve-sparing laparoscopic eradication of deep endometriosis with segmental rectal and parametrial resection: the Negrar method. a single-center,prospective,clinical trial[J]. Surg Endosc,2012,26(7):2029-2045.
25
Vizzielli G,Cosentino F,Raimondo D,et al. Real threedimensional approach vs two-dimensional camera with and without real-time near-infrared imaging with indocyanine green for detection of endometriosis: a case-control study[J]. Acta Obstet Gynecol Scand,2020,99(10):1330-1338.
26
Jayakumaran J,Pavlovic Z,Fuhrich D,et al. Robotic single-site endometriosis resection using near-infrared fluorescence imaging with indocyanine green: a prospective case series and review of literature[J]. J Robot Surg,2020,14(1):145-154.
27
De Neef A,Cadiere GB,Bourgeois P,et al. Fluorescence of deep infiltrating endometriosis during laparoscopic surgery: a preliminary report on 6 cases[J]. Surg Innov,2018,25(5):450-454.
28
Maheux-Lacroix S,Belanger M,Pinard L,et al. Diagnostic accuracy of intraoperative tools for detecting endometriosis: a systematic review and meta-analysis[J]. J Minim Invasive Gynecol,2020,27(2):433-440.
29
Raimondo D,Mastronardi M,Mabrouk M,et al. Rectosigmoid endometriosis vascular patterns at intraoperative indocyanine green angiography and their correlation with clinicopathological data[J].Surg Innov,2020,27(5):474-480.
30
Kanno K,Aiko K,Yanai S,et al. Clinical use of indocyanine green during nerve-sparing surgery for deep endometriosis[J]. Fertil Steril,2021,116(1):269-271.
31
Scioscia M,Bruni F,Ceccaroni M,et al. Distribution of endometriotic lesions in endometriosis stage IV supports the menstrual reflux theory and requires specific preoperative assessment and therapy[J]. Acta Obstet Gynecol Scand,2011,90(2):136-139.
32
Maccagnano C,Pellucchi F,Rocchini L,et al. Ureteral endometriosis: proposal for a diagnostic and therapeutic algorithm with a review of the literature[J]. Urol Int,2013,91(1):1-9.
33
Ceccaroni M,Ceccarello M,Caleffi G,et al. Total laparoscopic ureteroneocystostomy for ureteral endometriosis: a single-center experience of 160 consecutive patients [J]. J Minim Invasive Gynecol,2019,26(1):78-86.
34
Centini G,Labanca L,Afors K,et al. Laparoscopic dissection of the pelvic ureter: rules of engagement [J]. J Minim Invasive Gynecol,2019,26(4):604.
35
Mandovra P,Kalikar V,Patankar RV. Real-time visualization of ureters using indocyanine green during laparoscopic surgeries: can we make surgery safer? [J]. Surg Innov,2019,26(4):464-468.
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