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Chinese Journal of Laparoscopic Surgery(Electronic Edition) ›› 2024, Vol. 17 ›› Issue (06): 352-359. doi: 10.3877/cma.j.issn.1674-6899.2024.06.006

• Original Articles • Previous Articles     Next Articles

Efficacy of bronchoscopic lung volume reduction with one-way valve:a multicenter retrospective study

Qiang Zhu1, Hang Yu1, Mingxue Guo1, Yi Xu1, Minghui Zhu2, Xinyu Ti3, Wangping Li4, Hao Xu5, Yong Huang6, Haihong Wu7, Yunzhi Zhou8, Ye Gu9, Zhixin Liang1, Zhen Yang1, Liang′an Chen1,()   

  1. 1.The Eighth Medical Center of the Chinese PLA General Hospital,Beijing 100853,China
    2.Department of Thoracic Surgery,Zhongnan Hospital of Wuhan University,430071,China
    3.Department of Respiratory and Critical Care Medicine,The First Affiliated Hospital of Air Force Medical University,Xi′an 710005,China
    4.Department of Respiratory Medicine,The Second Affiliated Hospital of Air Force Medical University,Xi′an 710038,China
    5.Department of Respiratory Medicine,The Second Affiliated Hospital of Zhejiang University,Hangzhou 310009,China
    6.Department of Respiratory and Critical Care Medicine,Chongqing General Hospital,400799,China
    7.Department of Respiratory and Critical Care Medicine,Hainan General Hospital,Haikou 570311,China
    8.Department of Respiratory Medicine,Beijing Meitan General Hospital,100028,China
    9.Endoscopy Center,Shanghai Pulmonary Hospital,200433,China
  • Received:2024-11-27 Online:2024-12-30 Published:2025-02-12
  • Contact: Liang′an Chen

Abstract:

Objective

To assess the impact of endobronchial valve (EBV) treatment on lung function,exercise tolerance,clinical symptoms,and quality of life in patients with advanced emphysema,and to evaluate the clinical efficacy of EBV in patients with severe emphysema.

Method

From Sep. 2010 to Oct. 2022,patients with advanced emphysema who received EBV treatment in 15 hospitals in China were enrolled in this study. Clinical data and chest high-resolution CT imaging data were collected and used to establish a clinical database and an imaging database. The changes in lung function,exercise tolerance,clinical symptoms,and quality of life before and after treatment were analysed and the response rate of EBV treatment was calculated.

Result

136 patients diagnosed with advanced emphysema who received EBV treatment were included in this study. Of these patients,131 were male and 5 were female,with an average age of 60 ±8 years. The results indicated a significant improvement in the patients′ pulmonary function,exercise tolerance,clinical symptoms,and quality of life following treatment. Additionally,64.71% of cases had a TLVR≥350 ml,and 55.15% of cases achieved the minimal clinically important difference (MCID)in FEV1 improvement (≥12%). EBV efficacy was more pronounced in patients with TLVR≥350 ml,but 36.36% of patients with significant volume reduction did not obtain significant improvement in FEV1.

Conclusion

EBV treatment can improve lung function,exercise tolerance,clinical symptoms,and quality of life in patients with advanced emphysema. However,treatment response rates are still unsatisfactory.

Key words: Chronic obstructive pulmonary disease, Advanced emphysema, Endobronchial valve, Quantitative CT

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