To discuss the clinical feasibility and significance of accurately separating the adrenal arteries and veins by using the inferior vena cava as an anatomical landmark in retroperitoneal laparoscopic right adrenalectomy based on the experience in right adrenal surgery.

A retrospective analysis was conducted on 36 patients who have undergone retroperitoneal laparoscopic surgery due to right adrenal tumor in Linyi People′s Hospital from Jan. 2020 to Sep. 2021. Surgeries were performed by the same surgeon who is a senior attending physician and has done more than 300 adrenal surgeries. During the operation, inferior vena cava was used as an anatomical landmark to locate and separate adrenal arteries and veins while performing the entire or partial resection of the right adrenal gland.

All surgeries were successfully completed in 36 cases. The average operative time was 32 min and the mean intraoperative blood loss was 20 ml. The patients were ambulated at 16th h after surgery and the mean postoperative hospital stay was 2.4 d.

Using the inferior vena cava as an anatomical landmark to separate adrenal vessels in retroperitoneal laparoscopic right adrenalectomy helps safely isolate the adrenal arteries and veins according to anatomical relationships and accurately locate the central vein, which can improve visibility in the surgical field and reduce intraoperative blood loss.