To investigate the diagnostic value of laparoscopy combined with ultrasound technology in idiopathic retroperitoneal fibrosis(IRF) and summarize the clinical diagnostic and therapeutic characteristics of this disease.

Clinical data from 11 patients with pathologically confirmed IRF were collected. A retrospective analysis was conducted on their clinical manifestations, laboratory tests, and imaging features, with a detailed description of the method for obtaining pathological diagnosis using laparoscopy combined with ultrasound technology.

The 11 patients had a mean age of 53.3±7.6 years, comprising 7 males and 4 females. The predominant clinical symptoms were abdominal and lumbar pain(8/11). The median disease duration was 5(3, 11) months. CT or MRI revealed a retroperitoneal soft tissue density, yet the diagnosis remained indeterminate (0/11). All 11 patients underwent laparoscopy combined with ultrasound-guided biopsy of retroperitoneal masses, which confirmed IRF. The treatment regimen included prednisone + tamoxifen + mycophenolate mofetil. All patients were followed up for a median duration of 21(13.5, 27) months, showing significant reduction in lesion size and effective treatment outcomes.

IRF presents with non-specific clinical manifestations and blood test results, and has a low diagnostic confirmation rate by imaging, making differential diagnosis from retroperitoneal tumors challenging. Laparoscopy combined with ultrasound-guided technology enables the acquisition of pathological tissue for definitive diagnosis, effectively avoiding missed or misdiagnoses, with minimal surgical trauma and proven safety and efficacy.