To report the experience of single-site laparoscopic partial splenectomy in the treatment of pediatric spleen diseases.

A retrospective analysis of clinical data was conducted for 16 children with spleen diseases who underwent single-site laparoscopic partial splenectomy from Oct. 2017 to Oct. 2023.

(1) Preoperative clinical diagnoses and postoperative pathological confirmations: 5 cases of splenic cysts, 4 cases of splenic hamartomas, 4 cases of splenic vascular malformations, and 3 cases of hereditary spherocytosis. (2) Lesions located in the upper pole or lower pole of the spleen were resected respectively in 5 cases; lesions in the middle pole were observed in 3 cases, with 2 undergoing resection of the middle and lower poles, and 1 case converting to splenic artery ligation due to intraoperative bleeding; 3 cases of hereditary spherocytosis underwent resection of the middle, lower, and partial upper poles. (3) Fourteen cases were successfully completed using single-incision laparoscopic surgery, and two cases required an additional port in the left upper abdomen to complete the procedure. (4) All patients were smoothly discharged postoperatively without complications such as bleeding or infection. Follow-up ranged from 3 to 55 months, with no recurrence observed in benign tumors, and significant improvement in anemia for children with hereditary spherocytosis.

Single-incision laparoscopic partial splenectomy is a safe and feasible method for treating pediatric spleen diseases. It allows for the removal of lesions while preserving splenic function and provides optimal cosmetic outcomes.