To report the preliminary experience of robotic single-port laparoscopic surgery for benign gynecologic surgery by applying a domestic single-port serpentine-arm laparoscopic robot (SR-ENS-600) and to discuss the safety and feasibility of this surgical approach.

The clinical data of 21 patients who underwent the SR-ENS-600 single-port robotic surgery and 42 patients who were underwent the single-port laparoscopic surgery at the General Gynecology Center of Peking Union Medical College Hospital during the period of Apr. 2022 to Apr. 2023 were retrospectively analyzed, and the perioperative outcomes, inclueded operative time, intraoperative bleeding, hospital stay, intra-operative and postoperative complications, wound healing, were compared.

The mean operative times in the R-LESS and LESS groups were 99.00 (53.00, 130.00) and 50.00 (40.00, 70.00) minutes, respectively, and the mean intraoperative blood loss was 30.00 (20.00, 80.00) ml and 50.00 (50.00, 100.00) ml. All surgeries were successfully completed, without changing the surgical approach. The R-LESS group was higher than the LESS group in terms of surgical time, hospitalization time, and hematocrit changes.

Robotic single-port surgery using the SR-ENS-600 surgical system might be a safe and feasible surgical technique for various gynecological benign diseases.