The surgical progress of diagnosis and treatment of pancreatic neck cancer

doi:10.3877/cma.j.issn.1674-6899.2022.04.014

Abstract

Abstract:

Pancreatic cancer is one of the most common malignant tumors of the digestive system, which has the characteristics of high malignancy and strong invasiveness. The anatomical location of tumors has a key impact on the clinicopathological characteristics, diagnosis and treatment strategies, and prognosis of pancreatic cancer. Due to the clinical anatomical characteristics of its close proximity to vital blood vessels around the pancreas, the resectable rate of pancreatic neck cancer is lower than that of pancreatic cancer in other sites, and the tumor biological behavior is more aggressive, thus its surgical diagnosis and treatment strategies are also different. Based on the clinicopathological characteristics of pancreatic neck cancer and the current research progress of pancreatic cancer, this article reviews the progress of the diagnosis and treatment of pancreatic neck cancer under the background of a multidisciplinary team.

Key words: Pancreatic neck cancer, Surgery, Diagnosis and treatment

Li Yan, Haosheng Chang, Zhiming Zhao, Yongliang Chen. The surgical progress of diagnosis and treatment of pancreatic neck cancer[J]. Chinese Journal of Laparoscopic Surgery(Electronic Edition), 2022, 15(04): 252-256.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhqjwkzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-6899.2022.04.014

https://zhqjwkzz.cma-cmc.com.cn/EN/Y2022/V15/I04/252

References 39

1	Siegel RL, Miller KD, Fuchs HE, et al. Cancer Statistics, 2022[J]. CA Cancer J Clin，2022，72(1):7-33.
2	Bilimoria KY, Bentrem DJ, Ko CY, et al. Validation of the 6th edition ajcc pancreatic cancer staging system: report from the national cancer database[J]. Cancer, 2007，110(4):738-744.
3	胡建昆，周总光，杨开清．胰腺的应用解剖[J]. 世界华人消化杂志，2001，9(7):826-829.
4	刘树伟，王永贵．胰颈的矢状断面解剖及其临床意义[J]. 中国解剖学杂志，1994，12(2):135-137.
5	Gray H, Clemente CD. Gray’s Anatomy (30th American ed)[M]. Philadelphia: Lea&Febiger，1985，1503-1504.
6	赵振美，刘树伟，林祥涛，等．胰的冠状断层标本与磁共振对照研究[J].解剖学报，2005，36(5):523-527.
7	Ocuin LM, Sarmiento JM, Staley CA, et al. Comparison of central and extended pancreatectomy for lesions of the pancreatic neck[J]. Ann Surg Oncol，2008，15(8):2096-2103.
8	Strasberg SM, Sanchez LA, Hawkins WG, et al. Resection of tumors of the neck of the pancreas with venous invasion: the "whipple at the splenic artery (WATSA)" procedure[J]. J Gastrointest Surg, 2012，16(5):1048-1054.
9	Hirono S, Kawai M, Okada K, et al. Pancreatic neck cancer has specific and oncologic characteristics regarding portal vein invasion and lymph node metastasis[J]. Surgery，2016，159(2):426-440.
10	Lee M, Kwon W, Kim H, et al. The role of location of tumor in the prognosis of the pancreatic cancer[J]. Cancers(Basel)，2020，12(8):2036.
11	Erning FN, Mackay TM, Geest LGM, et al. Association of the location of pancreatic ductal adenocarcinoma (head, body, tail) with tumor stage, treatment, and survival: a population-based analysis[J]. Acta Oncol, 2018，57(12): 1655-1662.
12	Honda K, Katzke VA, Husing A, et al. CA19-9 and apolipoprotein-A2 isoforms as detection markers for pancreatic cancer: a prospective evaluation[J]. Int J Cancer, 2019，144(8):1877-1887.
13	Yan L, Chen YL, Su M, et al. A single-institution experience with open irreversible electroporation for locally advanced pancreatic carcinoma[J]. Chin Med J (Engl)，2016，129(24):2920-2925.
14	Huang X, Fan C, Zhu H, et al. Glypican-1-antibody-conjugated gd-au nanoclusters for fi/mri dual-modal targeted detection of pancreatic cancer[J]. Int J Nanomedicine, 2018，13:2585-2599.
15	Wang Q, Yan H, Jin Y, et al. A novel plectin/intergrin-targeted bispecific molecular probe for magnetic resonance/near-infrared imaging of pancreatic cancer[J].Biomaterials，2018，183:173-184.
16	Chu LC, Park S, Kawamoto S, et al. Utility of CT radiomics features in differentiation of pancreatic ductal adenocarcinoma from normal pancreatic tissue[J].AJR AM J Roentgenol，2019，213:349-357.
17	Chang N, Cui L, Luo Y, et al. Development and multicenter validation of a CT -based radiomics signature for discriminating histological grades of pancreatic ductal adenocarcinoma[J].Quant Imaging Med Surg，2020，10:692-702.
18	Huang L, Jansen L, Balavarca Y, et al. Resection of pancreatic cancer in europe and usa: an international large-scale study highlighting large variations[J]. Gut, 2019，68(1):130-139.
19	王琛，樊勇，夏博伟. 微创时代下胰腺癌诊疗进展[J/CD].中华腔镜外科杂志(电子版)，2019，12(5):311-316.
20	Katz MHG, Varadhachary GR, Fleming JB, et al. Serum CA 19-9 as a marker of resectability and survival in patients with potentially resectable pancreatic cancer treated with neoadjuvant chemoradiation[J].Ann Surg Oncol，2010，17:1794-1801.
21	Maulat C, Canivet C, Touraine C, et al. A new score to predict the resectability of pancreatic adenocarcinoma: the bacap score[J]. Cancers (Basel)，2020，12(4):783.
22	Oba A, Croce C, Hosokawa P, et al. Prognosis based definition of resectability in pancreatic cancer: a road map to new guidelines[J].Ann Surg，2022，275(1) : 175-181.
23	Chen Y, Tan C, Mai G, et al. Resection of pancreatic tumors involving the anterior surface of the superior mesenteric/portal veins axis: an alternative procedure to pancreaticoduodenectomy with vein resection[J].J Am Coll Surg，2013，217: 21-28.
24	Chen Y, Wang X, Ke N, et al. Inferior mesenteric vein serves as an alternative guide for transection of the pancreatic body during pancreaticoduodenectomy with concomitant vascular resection: a comparative study evaluating perioperative outcomes[J]. Eur J Med Res，2014，19:42.
25	Park SY, Shin WY, Choe YM, et al. Extended distal pancreatectomy for advanced pancreatic neck cancer[J]. Korean J Hepatobiliary Pancreat Surg，2014，18:77-83.
26	Hartwig W, Gluth A, Hinz U, et al.Total pancreatectomy for primary pancreatic neoplasms: renaissance of an unpopular operation[J].Ann Surg，2015，261:537-546.
27	Jegatheeswaran S, Baltatzis M, Jamdar S, et a1.Superior mesenteric artery(SMA) resection during pancreatectomy for malignant disease of the pancreas：a systematic review[J]. HPB(Oxford)，2017，19(6):483-490.
28	Glebova NO, Hicks CW, Tosoian JJ, et al. Outcomes of arterial resection during pancreatectomy for tumor[J].J Vasc Surg, 2016, 63(3):721-729.
29	Hirano S, Kondo S, Hara T, et al. Distal pancreatectomy with en bloc celiac axis resection for locally advanced pancreatic body cancer: long-term results[J]. Ann Surg, 2007，246(1):46-51.
30	Murakami Y, Nakagawa N, Kondo N, et al. Survival impact of distal pancreatectomy with en bloc celiac axis resection combined with neoadjuvant chemotherapy for borderline resectable or locally advanced pancreatic body carcinoma[J]. Pancreatology, 2021，21(3):564-572.
31	Nakamura T, Hirano S, Noji T, et al. Distal pancreatectomy with en bloc celiac axis resection (modified appleby procedure) for locally advanced pancreatic body cancer: a single-center review of 80 consecutive patients[J]. Ann Surg Oncol ，2016，12:23.
32	Yamamoto T, Satoi S, Kawai M, et al. Is distal pancreatectomy with en-bloc celiac axis resection effective for patients with locally advanced pancreatic ductal adenocarcinoma-multicenter surgical group study[J]. Pancreatology, 2018，18(1):106-113.
33	中国抗癌协会胰腺癌专业委员会．中国胰腺癌综合诊治指南(2020版)[J].中华外科杂志，2021，59(2):81-100.
34	Zhang B, Lee GC, Qadan M, et al. Revision of pancreatic neck margins based on intraoperative frozen section analysis is associated with improved survival in patients undergoing pancreatectomy for ductal adenocarcinoma[J].Ann Surg, 2021，274(2), 134-142.
35	Jang JY, Kang JS, Han YM, et al. Long-term outcomes and recurrence patterns of standard versus extended pancreatectomy for pancreatic head cancer: a multicenter prospective randomized controlled study[J].J Hepatobiliary Pancreat Sci，2017，24(7): 426-433.
36	Dillhoff M, Pawlik TM. Role of node dissection in pancreatic tumor resection[J]. Ann Surg Oncol，2021，28(4):2374-2381.
37	Versteijne E, Suker M, Groothuis K, et al. Preoperative chemoradiotherapy versus immediate surgery for resectable and borderline resectable pancreatic cancer: results of the dutch randomized phase Ⅲ preopanc trial[J]. J Clin Oncol，2020，38(16):1763-1773.
38	Tempero MA, Malafa MP, Al-Hawary M, et al. Pancreatic adenocarcinoma, version 2.2021, nccn clinical practice guidelines in oncology[J]. J Natl Compr Canc Netw，2021，19(4):439-457.
39	Van RS, Van VE, Klompmaker S, et al. Evaluation of adjuvant chemotherapy in patients with resected pancreatic cancer after neoadjuvant folfirinox treatment[J]. JAMA Oncol，2020，6:1733-1740.

[1]	Zhuoyan Xie, Yuanli Luo, Bin Qiao, Jinrui Li, Zhiyi Zhou, Zhigang Wang, Jianli Ren. Peptide-functionalized glucose oxidase-loaded phase-transformation and smart responsive nanoparticles for ultrasound imaging and breast cancer treatment [J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2022, 19(08): 837-846.
[2]	Hongyan Yu, Fengjiang Wang, Ning Ma, Taicheng Zhou. Application of enhanced recovery after surgery mode in Sugarbaker repair of parastomal hernia [J]. Chinese Archives of General Surgery(Electronic Edition), 2022, 16(05): 332-335.
[3]	Yuanyuan Yang, Heguang Huang, Yanchang Chen, Fengchun Lu, Xianchao Lin, Ronggui Lin, Congfei Wang. Clinical analysis of 18 cases with parastomal hernia treated by robotic and laparoscopic surgery [J]. Chinese Archives of General Surgery(Electronic Edition), 2022, 16(05): 336-340.
[4]	Huan Deng, Bo Cao, Jun Huang, Runkai Chen, Guibin Liu, Liqiang Song, Bo Wei. Progress of prevention and management of surgical complications in retroperitoneal tumor [J]. Chinese Archives of General Surgery(Electronic Edition), 2022, 16(05): 371-375.
[5]	Li Cao, Zhenyu Zhu, Fengxia Gong, Yang Yan, Zheng Peng, Guanglong Dong. Pseudomyxoma peritonei：report of 50 cases and review of literature [J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2022, 16(05): 530-532.
[6]	Haoyu Fu, Shaobo Tian, Xiangnan Yu, Yuan Li, Yang Cao, Zheng Wang, Guobin Wang. Application of robotic system in colorectal surgery [J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2022, 16(05): 572-575.
[7]	Li Ning, Yefeng Yin, Zheng Liu, Jinghe Lang, Xishan Wang. Evolution and prospect of transvaginal specimen extraction surgery [J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2022, 16(05): 580-583.
[8]	Rui Xu, Lu Peng, Junjie Zhou, Qun Qian. Comparison of the efficacy of domestic biological mesh and polypropylene mesh in daytime Lichtenstein repair of oblique inguinal hernia [J]. Chinese Journal of Hernia and Abdominal Wall Surgery(Electronic Edition), 2022, 16(05): 535-539.
[9]	Xing Wang, Kai Zhang, feng Zhan. Emergent pancreaticoduodenectomy and extended right hemicolectomy for abdominal injury: experiences of one case [J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2022, 11(05): 528-530.
[10]	Wenhao Luo, Zhe Cao, Taiping Zhang. Development and depate of robotic surgery in pancreatic surgery [J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2022, 11(05): 429-432.
[11]	Xiaorui Huang, Tong Guo, Zhiwei Zhang. Diagnosis and managements of intraductal papillary mucinous neoplasms and patient follow-up strategy [J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2022, 11(05): 449-452.
[12]	Yanmei Gu, Guangming Li, Shuangmei Xi, Xin Liu, Xiulian Wu, Xin Wang, Boxun Jin. Application of clustered ERAS regimen in recovery after liver transplantation [J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2022, 11(05): 476-481.
[13]	Xiaorui Ye, Heiying Jin, Chunxia Zhang. Necessity and existing problems of multidisciplinary integration for diagnosis and treatment of pelvic floor dysfunction [J]. Chinese Journal of Clinicians(Electronic Edition), 2022, 16(07): 605-609.
[14]	Zhongqing Wei, Qiang Xia. Exploring development and advantages of pelvic floor surgery from a holistic perspective [J]. Chinese Journal of Clinicians(Electronic Edition), 2022, 16(07): 610-613.
[15]	Peng Fu, Nian Shen, Yanling Huang, Shuiping Yang, Xiaobo Wan. Clinical features and prognosis of traumatic lens dislocation complicated with peripheral occult retinopathy [J]. Chinese Journal of Clinicians(Electronic Edition), 2022, 16(06): 536-540.

Please choose a citation manager

Content to export