To investigate the clinical feasibility and surgical strategies of laparoendoscopic single-site inguinal lymphadenectomy(LESS-IL)in the treatment of primary vaginal cancer, and to provide some experience and reference for its application of vaginal cancer.

We retrospectively analyzed clinical data and surgical strategies of two patients with primary vaginal cancer who were successfully implemented LESS-IL in the Department of Gynecology, Zhongda Hospital Affiliated to Southeast University from Jun.to Jul. 2018.

LESS-IL was successfully completed in total four sides of two patients, no case was conversion to conventional laparoscopic or open surgery. The mean operation time and intraoperative blood loss of each side was 45 min(35-55 min) and 45 ml (20-85 ml) respectively. The mean numbers of lymph nodes removed was 7.2 (6-9) in each side, and two (12%) positive lymph nodes were detected in one patient′s groin area. Both two cases were treated with sufficient drainage and the mean daily drainage volume was 32.5 ml(2-250 ml), while the drainage tube was all removed in the eighth postoperative day. Till now, no complications like incision infection, incision splitting, skin necrosis and lymphedema were observed in two cases, neither tumor recurrence and metastasis.

LESS-IL for treating primary vaginal cancer is safe and feasible, which could diminish postoperative complications.