Effect of surgical treatment of patients with lung cancer on postoperative stress reaction

doi:10.3877/cma.j.issn.1674-6899.2016.04.011

Abstract

Abstract:

Objective

Research and analysis of video-assisted thoracoscopic lung resection for the treatment of non-small cell lung cancer effect of postoperative stress response related indicators.

Methods

Take operation data were retrospectively analyzed in 92 cases of operation method in our hospital were admitted to Department of thoracic surgery lobectomy patients for statistical analysis, 39 cases (53 cases) were treated by using the latest video assisted thoracic surgery (Group) and conventional thoracotomy, to comparison difference of two groups of patients with surgical stress related indicators.

Results

There was no significant difference in the operation time, bleeding volume, postoperative drainage volume, postoperative drainage volume, time of drainage tube, the number of lymph nodes, length of hospital stay and the traditional group (P>0.05 ). The levels of COR, GH, PGE2 and P in patients with 1 , 3 , and 7 d were significantly lower than those in the traditional group (P<0.05). After the 1 , 3 , 7 d thoracoscopic group of patients with CRP, IL-6, TNF-a level was significantly lower than the traditional group of patients (P<0.05).

Conclusions

Video-assisted thoracoscopic lung resection surgery compared to traditional surgery in the treatment of non-small cell lung cancer with reliable in operation, small trauma, rapid recovery, postoperative stress reaction and low levels of advantages.

Key words: Thoracoscopic lobectomy, Operation, Non-small cell lung cancer, Stress response

Qiongyu Wang, Biao Li, Fu Li, Fan Li. Effect of surgical treatment of patients with lung cancer on postoperative stress reaction[J]. Chinese Journal of Laparoscopic Surgery(Electronic Edition), 2016, 09(04): 232-235.

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References 15

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组别	例数	手术时间(min)	术中出血量(ml)	术后引流量(ml)	胸腔引流管时间(d)	清扫淋巴结数目(枚)	住院时间(d)
胸腔镜组	39	186.3 ± 49.2	275.8 ± 49.3	674.9 ± 303.5	3.1 ± 1.3	16.7 ± 4.5	15.6 ± 7.8
传统组	53	169.8 ± 45.3	285.3 ± 47.0	789.4 ± 329.1	3.4 ± 1.5	18.2 ± 4.6	17.3 ± 8.1
t值	?	1.665	0.938	1.704	1.002	1.560	1.010
P值	?	0.092	0.245	0.076	0.221	0.082	0.227

组别	例数	手术时间(min)	术中出血量(ml)	术后引流量(ml)	胸腔引流管时间(d)	清扫淋巴结数目(枚)	住院时间(d)
胸腔镜组	39	186.3 ± 49.2	275.8 ± 49.3	674.9 ± 303.5	3.1 ± 1.3	16.7 ± 4.5	15.6 ± 7.8
传统组	53	169.8 ± 45.3	285.3 ± 47.0	789.4 ± 329.1	3.4 ± 1.5	18.2 ± 4.6	17.3 ± 8.1
t值	?	1.665	0.938	1.704	1.002	1.560	1.010
P值	?	0.092	0.245	0.076	0.221	0.082	0.227

组别		术前	术后第1天	术后第3天	术后第7天
胸腔镜组(39例)		?	?	?	?
?	皮质醇(ng/ml)	69.4 ± 21.5	93.5 ± 39.5^ab	115.3 ± 42.4^ab	84.3 ± 25.5^a
?	生长激素(ng/ml)	1.4 ± 0.8	2.1 ± 1.3^a	1.8 ± 1.0^b	1.2 ± 0.7
?	ACTH(ng/ml)	3.3 ± 1.0	2.8 ± 0.9	3.1 ± 0.9	3.2 ± 1.1
?	PGE2(pg/ml)	105.3 ± 13.7	181.9 ± 19.4^ab	192.6 ± 21.2^ab	135.4 ± 18.0^ab
?	P物质(μg/ml)	4.1 ± 0.7	9.3 ± 1.5^ab	9.4 ± 1.5^ab	5.3 ± 0.9^ab
传统组(53例)		?	?	?	?
?	皮质醇(ng/ml)	71.3 ± 22.6	115.7 ± 37.6^a	142.7 ± 43.9^a	91.5 ± 26.0^a
?	生长激素(ng/ml)	1.3 ± 0.9	2.6 ± 1.2^a	2.5 ± 1.1^a	1.8 ± 0.9
?	ACTH(ng/ml)	3.3 ± 1.0	2.9 ± 1.1	2.8 ± 1.0	3.1 ± 1.0
?	PGE2(pg/ml)	107.8 ± 14.0	199.5 ± 18.3^a	207.3 ± 23.0a	151.4 ± 21.7^a
?	P物质(μg/ml)	4.3 ± 0.9	10.5 ± 1.7^a	10.2 ± 1.6^a	6.4 ± 1.1^a

组别		术前	术后第1天	术后第3天	术后第7天
胸腔镜组(39例)		?	?	?	?
?	皮质醇(ng/ml)	69.4 ± 21.5	93.5 ± 39.5^ab	115.3 ± 42.4^ab	84.3 ± 25.5^a
?	生长激素(ng/ml)	1.4 ± 0.8	2.1 ± 1.3^a	1.8 ± 1.0^b	1.2 ± 0.7
?	ACTH(ng/ml)	3.3 ± 1.0	2.8 ± 0.9	3.1 ± 0.9	3.2 ± 1.1
?	PGE2(pg/ml)	105.3 ± 13.7	181.9 ± 19.4^ab	192.6 ± 21.2^ab	135.4 ± 18.0^ab
?	P物质(μg/ml)	4.1 ± 0.7	9.3 ± 1.5^ab	9.4 ± 1.5^ab	5.3 ± 0.9^ab
传统组(53例)		?	?	?	?
?	皮质醇(ng/ml)	71.3 ± 22.6	115.7 ± 37.6^a	142.7 ± 43.9^a	91.5 ± 26.0^a
?	生长激素(ng/ml)	1.3 ± 0.9	2.6 ± 1.2^a	2.5 ± 1.1^a	1.8 ± 0.9
?	ACTH(ng/ml)	3.3 ± 1.0	2.9 ± 1.1	2.8 ± 1.0	3.1 ± 1.0
?	PGE2(pg/ml)	107.8 ± 14.0	199.5 ± 18.3^a	207.3 ± 23.0a	151.4 ± 21.7^a
?	P物质(μg/ml)	4.3 ± 0.9	10.5 ± 1.7^a	10.2 ± 1.6^a	6.4 ± 1.1^a

组别		术前	术后第1天	术后第3天	术后第7天
胸腔镜组(39例)		?	?	?	?
?	皮质醇(mg/ml)	6.51 ± 2.40	30.52 ± 11.73	48.21 ± 14.96	18.34 ± 9.74
?	IL-6(μg/ml)	0.13 ± 0.05	0.21 ± 0.07	0.27 ± 0.09	0.17 ± 0.06
?	TNF-ɑ(μg/ml)	3.28 ± 1.04	7.22 ± 1.31	7.59 ± 1.39	5.19 ± 1.20
传统组(53例)		?	?	?	?
?	皮质醇(mg/ml)	6.60 ± 2.56	34.98 ± 11.72	57.95 ± 15.08	27.96 ± 10.85
?	IL-6(μg/ml)	0.14 ± 0.06	0.30 ± 0.10	0.35 ± 0.11	0.23 ± 0.08
?	TNF-ɑ(μg/ml)	3.39 ± 1.16	8.02 ± 1.26	8.47 ± 1.40	6.13 ± 1.37

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