切换至 "中华医学电子期刊资源库"

中华腔镜外科杂志(电子版) ›› 2022, Vol. 15 ›› Issue (04): 211 -216. doi: 10.3877/cma.j.issn.1674-6899.2022.04.005

论著

经口腔前庭入路机器人甲状腺手术神经保护的探索
刘懿心1, 朱见2, 刘长瑞2, 王丹2, 周鹏2, 王猛2, 李陈钰2, 贺青卿2,()   
  1. 1. 250014 济南,山东中医药大学第一临床医学院;250031 济南,解放军联勤保障部队第九六〇医院甲状腺乳腺外科
    2. 250031 济南,解放军联勤保障部队第九六〇医院甲状腺乳腺外科
  • 收稿日期:2022-05-19 出版日期:2022-08-30
  • 通信作者: 贺青卿
  • 基金资助:
    国家重点研发计划专题项目(2019YFC0119205); 济南市临床医学科技创新计划(202019010)

Exploration of neuroprotection of transoral robotic thyroidectomy

Yixin Liu1, Jian Zhu2, Changrui Liu2, Dan Wang2, Peng Zhou2, Meng Wang2, Chenyu Li2, Qingqing He2,()   

  1. 1. First Clinical Medical College, Shangdong University of Traditional Chinese Medicine, Jinan 250014, China.; Department of Thyroid and Breast Surgery, The 960th Hospital of the PLA Joint Logistics Support Force, Jinan 250031, China
    2. Department of Thyroid and Breast Surgery, The 960th Hospital of the PLA Joint Logistics Support Force, Jinan 250031, China
  • Received:2022-05-19 Published:2022-08-30
  • Corresponding author: Qingqing He
目的

探讨经口腔前庭入路达芬奇机器人甲状腺手术(transoral robotic thyroidectomy,TORT)中神经保护的方法。

方法

回顾性分析2020年5月至2021年11月于解放军第九六〇医院甲状腺乳腺外科行TORT的70例患者的临床资料,其中男8例、女62例,年龄15~55岁、平均年龄(31.59±9.65)岁;其中良性患者12例、恶性患者58例,所有患者均采用精细化被膜解剖联合术中神经监测(intraoperative neuromonitoring,IONM)的方法解剖显露喉返神经并规避喉上神经外支(external branch of superior laryngeal nerve,EBSLN),规避颏神经及面神经下颌缘支走行区域的方法保护其功能,统计甲状腺肿瘤患者的临床数据,并评估手术相关神经功能,应用SPSS 23.0软件进行统计学分析。

结果

本研究所有手术均顺利完成,无中转开放。所有病例中,因面神经下颌缘支损伤导致口角歪斜1例(1.4%)、暂时性喉返神经麻痹1例(1.4%),无颏神经、EBSLN及永久性喉返神经损伤。

结论

对于TORT,IONM解剖显露喉返神经并规避EBSLN可有效保护喉神经的功能,规避颏神经及面神经下颌缘支走行区域可降低相关神经损伤风险。

Objective

To explore the method of nerve protection in da Vinci robotic thyroid surgery through oral vestibular approach.

Methods

The clinical data of 70 patients who underwent transoral da Vinci robotic thyroidectomy in the Department of Thyroid and Breast Surgery of 960th Hospital of PLA from May 2020 to Nov.2021 were retrospectively analysis, including 8 males and 62 females. The age ranged from 15 to 55 years old, with an average age of (31.59±9.65) years. Among them, there were 12 benign patients and 58 malignant patients. In all patients, the method of refined capsule dissection combined with intraoperative nerve monitoring was used to dissect the recurrent laryngeal nerve and avoid the superior laryngeal nerve, protect the function of the mental nerve and the marginal mandibular branch of facial nerve by avoiding the area where they run. The clinical data of thyroid tumor patients were collected and the neurological function related to surgery was evaluated. SPSS 23.0 software was used for statistical analysis.

Results

In this study, all operations were successfully completed with none transferred to open surgery. Among all the cases, 1 case(1.4%) had a skewed corner of the mouth due to the marginal mandibular branch of facial nerve injury, 1 case(1.4%) had temporary recurrent laryngeal nerve palsy, and there was no mental nerve, superior laryngeal nerve and permanent recurrent laryngeal nerve injury.

Conclusions

In robotic thyroid surgery through oral vestibular approach, refined capsule anatomy combined with intraoperative nerve monitoring anatomy to expose the recurrent laryngeal nerve and avoid the superior laryngeal nerve can effectively protect the function of the laryngeal nerve, and avoiding the mental nerve and marginal mandibular branch of facial nerve can reduce the risk of associated nerve injury.

图1 经口腔前庭入路机器人甲状腺手术外景照注:A.术前标记;B.下唇系带前方"上弧形"切口作为观察孔;C.左侧口角外侧颊黏膜处切口为操作孔;D.右侧口角切口;E.置入口腔套管;F.连接机械臂
图2 经口腔前庭入路机器人甲状腺手术的手术步骤注:A.离断峡部;B.凝切甲状腺中静脉;C.处理甲状腺上极,原位保留上位甲状旁腺;D.显露喉返神经
表1 70例经口腔前庭入路机器人甲状腺手术患者的手术范围[例(%)]
表2 70例经口腔前庭入路达芬奇机器人甲状腺手术的患者的临床资料
1
Lee HY, You JY, Woo SU, et al. Transoral periosteal thyroidectomy: cadaver to human[J]. Surg Endosc201529(4):898-904.
2
Anuwong A, Ketwong K, Jitpratoom P, et al. Safety and outcomes of the transoral endoscopic thyroidectomy vestibular approach[J].JAMA Surg, 2018, 153(1):21-27.
3
Liu MZ, Li MY, Yong W, et al. Comparison of the transoral endoscopic thyroidectomy vestibular approach and open thyroidectomy: a propensity score-matched analysis of surgical outcomes and safety in the treatment of papillary thyroid carcinoma[J]. Surgery, 2021170(6):1680-1686.
4
Sun H, Zheng H, Wang X, et al. Comparison of transoral endoscopic thyroidectomy vestibular approach, total endoscopic thyroidectomy via areola approach, and conventional open thyroidectomy: a retrospective analysis of safety, trauma, and feasibility of central neck dissection in the treatment of papillary thyroid carcinoma[J]. Surg Endosc, 2020, 34(1):268-274.
5
Tai D, Kim HY, Park D, et al. Obesity may not affect outcomes of transoral robotic thyroidectomy: subset analysis of 304 patients[J]. Laryngoscope, 2020, 130(5):1343-1348.
6
中国医师协会外科医师分会甲状腺外科医师委员会,中国研究型医院学会甲状腺疾病专业委员,海峡两岸医药卫生交流协会台海甲状腺微创美容外科专家委员会,等.经口腔前庭入路腔镜甲状腺手术专家共识(2018版)[J]. 中国实用外科杂志2018, 38(10):1104-1107.
7
中国医师协会外科医师分会甲状腺外科医师委员会,中国研究型医院学会甲状腺疾病专业委员会.机器人手术系统辅助甲状腺和甲状旁腺手术专家共识[J].中国实用外科杂志201636(11):1165-1170.
8
李小磊,贺青卿,李陈钰,等.经口腔前庭入路机器人甲状腺手术30例临床分析[J].中华外科杂志202159(12):994-998.
9
王丹,贺青卿.达芬奇机器人甲状腺手术的进展与展望[J].中国普外基础与临床杂志202128(10):1261-1265.
10
朱一鸣,刘绍严.再谈甲状腺手术喉返神经损伤的相关因素[J].中国实用外科杂志2018, 38(6):607-612.
11
王丹,朱见,周鹏,等.喉返神经监测仪在da Vinci机器人甲状腺癌手术中的应用[J]. 中国耳鼻咽喉头颈外科201825(8):423-427.
12
Erol V, Dionigi G, Barczyński M, et al. Intraoperative neuromonitoring of the RLNs during TOETVA procedures[J]. Gland Surg, 2020, 9(2):129-135.
13
Chuang FJ, Chen JY, Shyu JF, et al. Surgical anatomy of the external branch of the superior laryngeal nerve in chinese adults and its clinical applications[J]. Head Neck, 201032:53-57.
14
Uludag M, Aygun N, Kartal K, et al. Contribution of intraoperative neural monitoring to preservation of the external branch of the superior laryngeal nerve: a randomized prospective clinical trial[J]. Langenbecks Arch Surg, 2017, 402(6):965-976.
15
Gurleyik E, Gurleyik G. Intraoperative monitoring of external branch of the superior laryngeal nerve: functional identification, motor integrity, and its role on vocal cord function[J].J Invest Surg, 2018, 31(6):509-514.
16
中国医师协会外科医师分会甲状腺外科医师委员会,中国研究型医院学会甲状腺疾病专业委员会,中国医疗保健国际交流促进会临床实用技术分会,等.机器人甲状腺及甲状旁腺手术中神经电生理监测临床操作专家共识(2019版)[J].中国实用外科杂志201939(12):1248-1253.
17
Potenza AS, Araujo Filho VJ, Cernea CR. Injury of the external branch of the superior laryngeal nerve in thyroid surgery[J]. Gland Surg, 2017, 6(5):552-562.
18
Shan L, Liu J.A systemic review of transoral thyroidectomy[J]. Surg Laparosc Endosc Percutan Tech, 2018, 28(3):135-138.
19
Chen S, Zhao M, Qiu J. Transoral vestibule approach for thyroid disease: a systematic review[J]. Eur Arch Otorhinolaryngol, 2019, 276(2):297-304.
20
李慧,彭小伟,李赞,等.改良经口入路腔镜甲状腺手术的临床应用分析[J].中华外科杂志201957(9):686-690.
21
Yang HM, Shin KJ, Min J, et al. Anatomical study of gasless transoral thyroidectomy and clinical application[J].Surg Endosc, 202034:3414-3423.
22
张彬,韩宗辉,Bikash Rai. 经口腔达芬奇机器人甲状腺手术初步经验[J/CD]. 中华腔镜外科杂志(电子版)201811(4): 234-237.
23
刘磐,柏舒科,彭利伟,等. 面神经分支与口角平面位置关系的解剖学研究[J]. 中华口腔医学杂志201752(10):637-640.
[1] 金壮, 朱亚琼, 张诗杰, 宋青, 罗渝昆. 基于甲状腺成像报告和数据系统分类的计算机辅助诊断系统对甲状腺癌超声诊断的辅助价值[J]. 中华医学超声杂志(电子版), 2022, 19(05): 440-446.
[2] 杨满, 谢丽, 林栋材, 曹箭, 高纪东. 乳腺癌甲状腺转移一例[J]. 中华乳腺病杂志(电子版), 2022, 16(03): 196-197.
[3] 李磊, 崔思倩, 张慧强, 赵芳, 刘静. 桥本甲状腺炎与甲状腺癌关系研究进展[J]. 中华普通外科学文献(电子版), 2022, 16(04): 308-312.
[4] 张娜, 易茂林. 微波消融术与甲状腺腺叶切除术对BRAFV600E基因野生型cN0甲状腺微小乳头状癌临床效果对比研究[J]. 中华普通外科学文献(电子版), 2022, 16(01): 9-13.
[5] 梁加亮, 王永永, 张建勇, 赵代伟, 王南鹏, 李翼. 经口腔前庭入路单侧甲状腺癌手术的学习曲线(附48例经验总结)[J]. 中华普外科手术学杂志(电子版), 2022, 16(05): 549-553.
[6] 闵逸洋, 赵宁, 王沛豪. cT1N0期甲状腺癌三种腔镜术式和开放术式的对比研究[J]. 中华普外科手术学杂志(电子版), 2022, 16(04): 443-446.
[7] 陈伟, 邱钧, 李志贵, 朱锋, 唐国华, 李添亮. 胸锁乳突肌肌间入路对桥本病合并甲状腺乳头状癌临床运用分析[J]. 中华普外科手术学杂志(电子版), 2022, 16(04): 447-450.
[8] 王科, 张海鹏, 徐大道, 赵琳. 喉上神经外支监测技术在甲状腺上极肿瘤手术中的应用[J]. 中华普外科手术学杂志(电子版), 2022, 16(03): 331-334.
[9] 鞠后琼, 刘东宁, 仲崇晗, 何鹏辉, 叶善平, 王大强, 李太原. 机器人腹部无辅助切口经直肠取出标本的右半结肠合并中位直肠癌根治术(附视频)[J]. 中华结直肠疾病电子杂志, 2022, 11(02): 172-176.
[10] 王大强, 朱伟群, 刘东宁, 仲崇晗, 鞠后琼, 李太原. 体外离断直肠在NOSES Ⅰ式低位直肠癌根治术中的应用(附六例报告)[J]. 中华结直肠疾病电子杂志, 2022, 11(01): 86-88.
[11] 徐如祥, 邱文乔. 生物组装类脑生态位促进神经再生修复展望[J]. 中华神经创伤外科电子杂志, 2022, 08(01): 1-5.
[12] 王航, 蔡亚宁, 衡立君, 葛顺楠, 屈延. 创伤性视神经损伤预后影响因素分析及视神经管骨折手术策略选择[J]. 中华神经创伤外科电子杂志, 2022, 08(01): 23-27.
[13] 杨晓东, 陈煜辉, 麦奇光, 李涛, 朱振华, 樊仕才. 腹腔镜下神经松解术治疗骨盆骨折合并腰骶干神经损伤的初步临床疗效评估[J]. 中华老年骨科与康复电子杂志, 2022, 08(01): 4-9.
[14] 张黎. 周围神经外科亚专科的诊疗范畴[J]. 中华脑科疾病与康复杂志(电子版), 2021, 11(06): 321-324.
[15] 姚瑞鑫, 郭会利, 王波, 陈丽媛. 磁共振成像对臂丛神经损伤诊断价值的meta分析[J]. 中华消化病与影像杂志(电子版), 2021, 11(06): 286-290.
阅读次数
全文


摘要