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中华腔镜外科杂志(电子版) ›› 2020, Vol. 13 ›› Issue (04) : 218 -222. doi: 10.3877/cma.j.issn.1674-6899.2020.04.006

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论著

腹腔镜"蘑菇状"剜除术治疗外生性肾血管平滑肌脂肪瘤的临床应用
朱大庆1, 郭刚2, 邵雪3, 顾良友2, 王毅4,()   
  1. 1. 570100 海南医学院第二附属医院泌尿外科;100853 北京,解放军总医院泌尿外科
    2. 100853 北京,解放军总医院泌尿外科
    3. 572013 海南,解放军总医院海南医院神经内科
    4. 570100 海南医学院第二附属医院泌尿外科
  • 收稿日期:2020-04-07 出版日期:2020-08-30
  • 通信作者: 王毅

Clinical application of laparoscopic mushroom shaped enucleation in the treatment of ectopic renal angiomyolipoma

Daqing Zhu1, Gang Guo2, Xue Shao3, Liangyou Gu2, Yi Wang4,()   

  1. 1. Department of The Second Affiliated Hospital of Hainan Medical College, Hainan 570100, China.; Department of Urology, Chinese PLA General Hospital, Beijing 100853, China
    2. Department of Urology, Chinese PLA General Hospital, Beijing 100853, China
    3. Department of Neurology, Hainan Hospital, PLA General Hospital, Hainan 572013, China
    4. Department of The Second Affiliated Hospital of Hainan Medical College, Hainan 570100, China
  • Received:2020-04-07 Published:2020-08-30
  • Corresponding author: Yi Wang
  • About author:
    Corresponding author: Wang Yi, Email:
引用本文:

朱大庆, 郭刚, 邵雪, 顾良友, 王毅. 腹腔镜"蘑菇状"剜除术治疗外生性肾血管平滑肌脂肪瘤的临床应用[J/OL]. 中华腔镜外科杂志(电子版), 2020, 13(04): 218-222.

Daqing Zhu, Gang Guo, Xue Shao, Liangyou Gu, Yi Wang. Clinical application of laparoscopic mushroom shaped enucleation in the treatment of ectopic renal angiomyolipoma[J/OL]. Chinese Journal of Laparoscopic Surgery(Electronic Edition), 2020, 13(04): 218-222.

目的

对比研究腹腔镜下外生性肾血管平滑肌脂肪瘤"蘑菇状"剜除与标准肾部分切除术的安全性及有效性,为肾血管平滑肌脂肪瘤腹腔镜下"蘑菇状"剜除术术式的建立提供临床依据。

方法

选取海南医学院第二附属医院与解放军总医院2018年1月至2019年5月期间,接受腹腔镜手术的肾血管平滑肌脂肪瘤患者53例,其中25例沿肿瘤假包膜行"蘑菇状"剜除术(A组)、28例行肾部分切除术(B组)。比较两组手术患者的肾动脉阻断时间、手术时间、术中出血量、术后24 h血红蛋白、术后eGFR(estimated glomerular filtration rate,估计肾小球率过滤)的变化、术后住院时间和术后肿瘤复发率。

结果

53例手术无术中转开放,无死亡病例。肾动脉阻断时间:A组(11.9±2.2)min、B组(21.5±6.5) min(P<0.001)。手术时间:A组(87.9±24.8)min、B组(114.3±38.9) min(P<0.001)。术中出血量:A组20 ml(20~40)ml、B组50 ml(50~100)ml(P<0.001)。术后24 h血红蛋白变化:A组(7.4±4.3) g/L、B组(12.4±8.8) g/L(P=0.013)。术后24 h eGFR变化:A组(6.2±7.2 )ml(min·1.73 m2),B组(12.7±12.8)ml(min·1.73 m2)(P=0.027)。术后6个月eGFR变化:A组(1.5±3.7)ml(min·1.73 m2)、B组(6.5±5.6)ml(min·1.73 m2)(P<0.001)。术后住院时间:A组4.0 d(3~4)d、B组4.5 d(3~6)d(P=0.023)。术后随访两组术后肿瘤均无复发。

结论

采用腹腔镜"蘑菇状"剜除术治疗外生性肾血管平滑肌脂肪瘤在肾动脉阻断时间、术中出血量、术后24 h血红蛋白、术后eGFR变化、术后住院时间等方面均优于传统肾部分切除术,两组术后肿瘤均无复发;该方法安全、有效,适于临床推广。

Objective

To compare the safety and efficacy of laparoscopic "mushroom" enucleation and standard partial nephrectomy for ectopic renal angiomyolipoma, so as to provide clinical basis for the establishment of laparoscopic "mushroom" enucleation of renal angiomyolipoma.

Methods

From Jan.2018 to May 2019, 53 patients with renal angiomyolipoma underwent laparoscopic surgery in the Second Affiliated Hospital of Hainan Medical College and the Chinese PLA General Hospital. Among them, 25 cases underwent mushroom shaped enucleation along the pseudocapsule of the tumor (group A), 28 cases underwent partial nephrectomy (group B). The changes of renal artery occlusion time, operation time, intraoperative blood loss, preoperative and postoperative hemoglobin and eGFR (estimated glomerular filtration rate) were compared between the two groups.

Results

53 cases of operation were not converted to open, no death cases. renal artery occlusion time: (11.9 ± 2.2)min in group A. (21.5 ± 6.5)min in group B(P< 0.001). Operation time: ( 87.9 ± 24.8) min in group A. (114.3 ± 38.9) min in group B(P< 0.001). Intraoperative blood loss: group A: 20 ml(20-40)ml. group B: 50 ml(50-100)ml(P< 0.001). The change of hemoglobin 24 hours after operation: group A: (7.4±4.3)g/L. group B: (12.4±8.8)g/L(P=0.013). 24 hours after operation, the change of eGFR was (6.2 ± 7.2) ml (min·1.73 m2) in group A, (12.7 ± 12.8) ml (min·1.73 m2) in group B(P= 0.027). The change of eGFR in group A was (1.5 ± 3.7)ml(min·1.73 m2), and in group B was( 6.5 ± 5.6) ml(min·1.73 m2)(P< 0.001). Postoperative hospitalization days, group A: 4.0(3-4)days; group B: 4.5(3-6)days(P= 0.023). Postoperative follow-up: there was no recurrence in both groups.

Conclusions

Laparoscopic "mushroom" enucleation for ectopic renal angiomyolipoma was superior to traditional partial nephrectomy in terms of renal artery occlusion time, intraoperative blood loss, changes of hemoglobin and eGFR, and length of hospital stay. There was no recurrence of tumor in both groups. This method is safe and effective and suitable for clinical application.

图1 蘑菇状生长的错构瘤
图2 分离出肾动脉后用阻断带对肾动脉预控制
图3 沿着肿瘤包膜与肾被膜之间的间隙分离至显露出肿瘤基底部,
图4 术后标本
表1 肾血管平滑肌脂肪瘤患者的两组临床资料
表2 肾血管平滑肌脂肪瘤患者的两组术中及术后临床安全性指标
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