探讨腹腔镜联合超声技术在特发性腹膜后纤维化中的诊断价值，总结分析该病临床诊治特点。

收集2021年1月至2024年12月于新疆维吾尔自治区人民医院就诊的11例病理确诊为特发性腹膜后纤维化患者临床资料，回顾性分析其临床表现、实验室检查、影像学检查特点，详细阐述应用腹腔镜联合超声技术获得病理诊断的方法。

11例患者平均年龄53.3±7.6岁，男7例，女4例，临床不适以腹部、腰部疼痛为主(8/11)，中位病程5(3，11)个月，CT或MRI检查提示腹膜后软组织密度影，但无法明确诊断(0/11)。11例患者均行腹腔镜联合超声引导下腹膜后肿物活检获得病理组织，确诊为特发性腹膜后纤维化。治疗方案为泼尼松＋他莫西芬＋吗替唛考吩酯，均获得随访，中位随访时间为21(13.5，27)个月，病灶显著缩小，诊疗有效。

特发性膜后纤维化临床表现及血液检验无特异性，影像学确定诊断率低，与腹膜后肿瘤鉴别诊断困难。腹腔镜联合超声引导技术可获得病理组织，达到确诊目的，有效避免漏诊、误诊，手术创伤小，安全有效。

To investigate the diagnostic value of laparoscopy combined with ultrasound technology in idiopathic retroperitoneal fibrosis(IRF) and summarize the clinical diagnostic and therapeutic characteristics of this disease.

Clinical data from 11 patients with pathologically confirmed IRF were collected. A retrospective analysis was conducted on their clinical manifestations, laboratory tests, and imaging features, with a detailed description of the method for obtaining pathological diagnosis using laparoscopy combined with ultrasound technology.

The 11 patients had a mean age of 53.3±7.6 years, comprising 7 males and 4 females. The predominant clinical symptoms were abdominal and lumbar pain(8/11). The median disease duration was 5(3, 11) months. CT or MRI revealed a retroperitoneal soft tissue density, yet the diagnosis remained indeterminate (0/11). All 11 patients underwent laparoscopy combined with ultrasound-guided biopsy of retroperitoneal masses, which confirmed IRF. The treatment regimen included prednisone + tamoxifen + mycophenolate mofetil. All patients were followed up for a median duration of 21(13.5, 27) months, showing significant reduction in lesion size and effective treatment outcomes.

IRF presents with non-specific clinical manifestations and blood test results, and has a low diagnostic confirmation rate by imaging, making differential diagnosis from retroperitoneal tumors challenging. Laparoscopy combined with ultrasound-guided technology enables the acquisition of pathological tissue for definitive diagnosis, effectively avoiding missed or misdiagnoses, with minimal surgical trauma and proven safety and efficacy.