切换至 "中华医学电子期刊资源库"

中华腔镜外科杂志(电子版) ›› 2021, Vol. 14 ›› Issue (03): 129 -136. doi: 10.3877/cma.j.issn.1674-6899.2021.03.001

专家共识    下一篇

乙型病毒性肝炎相关肝细胞癌围手术期抗病毒治疗规范
中国研究型医院学会微创外科学专业委员会   
  • 收稿日期:2021-05-07 出版日期:2021-08-18
  • 基金资助:
    国家科技重大专项课题(2018ZX10302204-003)

Expert consensus of perioperative antiviral therapy for hepatitis B-associated hepatocellular carcinoma

Professional Committee of Minimally Invasive Surgery of Chinese Research Hospital Association   

  • Received:2021-05-07 Published:2021-08-18
1
Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2021,71(3): 209-249.
2
Zeng H, Chen W, Zheng R, et al. Changing cancer survival in china during 2003-15: a pooled analysis of 17 population-based cancer registries[J]. Lancet Glob Health, 2018,6(5): 555-567.
3
中华人民共和国国家卫生健康委员会医政医管局. 原发性肝癌诊疗规范(2019年版)[J]. 中国实用外科杂志,2020,40(2): 121-138.
4
中华医学会感染病学分会.慢性乙型肝炎防治指南(2019年版)[J]. 中华肝脏病杂志,2019,27(12): 938-961.
5
中国抗癌协会肝癌专业委员会.中国肝癌多学科综合治疗专家共识[J]. 临床肝胆病杂志,2021,37(2): 278-285.
6
中华预防医学会肿瘤预防与控制专业委员会感染相关肿瘤防控学组,中华预防医学会慢病预防与控制分会,中华预防医学会健康传播分会.中国肝癌一级预防专家共识(2018) [J].中华预防医学杂志,2019,4(1): 36-44.
7
Mak LY, Cruz-Ramón V, Chinchilla-López P, et al. Global epidemiology, prevention, and management of hepatocellular carcinoma[J]. Am Soc Clin Oncol Educ Book,2018,38(4): 262-279.
8
Fattovich G, Bortolotti F, Donato F. Natural history of chronic hepatitis B: special emphasis on disease progression and prognostic factors[J]. J Hepatol,2008,48(2): 335-352.
9
Chu CM, Liaw YF. Hepatitis b virus-related cirrhosis: natural history and treatment[J]. Semin Liver Dis,2006,26(2): 142-152.
10
McMahon BJ, Holck P, Bulkow L, et al. Serologic and clinical outcomes of 1536 alaska natives chronically infected with hepatitis b virus[J]. Ann Intern Med,2001,135(9): 759-768.
11
Tseng TC, Liu CJ, Yang HC, et al. Serum hepatitis b surface antigen levels help predict disease progression in patients with low hepatitis b virus loads[J]. Hepatology,2013,57(2): 441-450.
12
Tseng TC, Liu CJ, Hsu CY, et al. High level of hepatitis b core-related antigen associated with increased risk of hepatocellular carcinoma in patients with chronic hbv infection of intermediate viral load[J]. Gastroenterology,2019,157(6): 1518-1529.
13
An P, Xu J, Yu Y, et al. Host and viral genetic variation in hbv-related hepatocellular carcinoma[J]. Front Genet,2018,9(5): 261.
14
Ning Q, Han M, Sun Y, et al. Switching from entecavir to pegifn alfa-2a in patients with hbeag-positive chronic hepatitis b: a randomised open-label trial (osst trial) [J]. J Hepatol,2014,61(4): 777-784.
15
Hu P, Shang J, Zhang W, et al. Hbsag loss with peg-interferon alfa-2a in hepatitis b patients with partial response to nucleos(t)ide analog: new switch study[J]. J Clin Transl Hepatol,2018,6(1): 25-34.
16
王贵强,王福生,成军,等.慢性乙型肝炎防治指南(2015更新版)[J].中华肝脏病杂志,2015,23(12): 888-905.
17
Lampertico P, Agarwal K, Berg T, et al. EAsl 2017 clinical practice guidelines on the management of hepatitis b virus infection[J]. J Hepatol,2017,67(2): 370-398.
18
Terrault NA, Lok ASF, McMahon BJ, et al. Update on prevention, diagnosis, and treatment of chronic hepatitis b: aasld 2018 hepatitis b guidance[J]. Hepatology,2018,67(4): 1560-1599.
19
中华医学会感染病学分会,中华医学会肝病学分会.慢性乙型肝炎临床治愈(功能性治愈)专家共识[J]. 中华肝脏病杂志,2019, 27(8): 594-603.
20
Chan HLY, Chan FWS, Hui AJ, et al. Switching to peginterferon for chronic hepatitis b patients with hepatitis b e antigen seroconversion on entecavir-a prospective study[J]. J Viral Hepat, 2019,26(1): 126-135.
21
Kumada T, Toyoda H, Tada T, et al. Effect of nucleos(t)ide analogue therapy on hepatocarcinogenesis in chronic hepatitis b patients: a propensity score analysis[J]. J Hepatol,2013,58(3): 427-433.
22
Hosaka T, Suzuki F, Kobayashi M, et al. Long-term entecavir treatment reduces hepatocellular carcinoma incidence in patients with hepatitis b virus infection[J]. Hepatology,2013,58(1): 98-107.
23
Liu K, Choi J, Le A, et al. Tenofovir disoproxil fumarate reduces hepatocellular carcinoma, decompensation and death in chronic hepatitis b patients with cirrhosis[J]. Aliment Pharmacol Ther,2019,50(9): 1037-1048.
24
Ikeda K, Saitoh S, Suzuki Y, et al. Interferon decreases hepatocellular carcinogenesis in patients with cirrhosis caused by the hepatitis b virus: a pilot study[J]. Cancer,1998,82(5): 827-835.
25
Jiang XY, Huang B, Huang DP, et al. Long-term follow-up of cumulative incidence of hepatocellular carcinoma in hepatitis b virus patients without antiviral therapy[J]. World J Gastroenterol,2021,27(11): 1101-1116.
26
Chen CF, Lee WC, Yang HI, et al. Changes in serum levels of hbv dna and alanine aminotransferase determine risk for hepatocellular carcinoma[J]. Gastroenterology,2011,141(4): 1240-1248.
27
Wu CY, Lin JT, Ho HJ, et al. Association of nucleos(t)ide analogue therapy with reduced risk of hepatocellular carcinoma in patients with chronic hepatitis b: a nationwide cohort study[J]. Gastroenterology,2014,147(1): 143-151.
28
Zhang W, Wang X, Wang Y, et al. Effective viral suppression is necessary to reduce hepatocellular carcinoma development in cirrhotic patients with chronic hepatitis b: results of a 10-year follow up[J]. Medicine (Baltimore),2017,96(44): 8454-8454.
29
Cho JY, Paik YH, Sohn W, et al. Patients with chronic hepatitis b treated with oral antiviral therapy retain a higher risk for hcc compared with patients with inactive stage disease[J]. Gut, 2014,63(12): 1943-1950.
30
Zhou TC, Lai X, Feng MH, et al. Systematic review and meta-analysis: development of hepatocellular carcinoma in chronic hepatitis b patients with hepatitis e antigen seroconversion[J]. J Viral Hepat,2018,25(1): 1172-1179.
31
Yip TC, Chan HL, Wong VW, et al. Impact of age and gender on risk of hepatocellular carcinoma after hepatitis b surface antigen seroclearance[J]. J Hepatol,2017,67(5): 902-908.
32
Yip TC, Wong GL, Chan HL, et al. Hbsag seroclearance further reduces hepatocellular carcinoma risk after complete viral suppression with nucleos(t)ide analogues[J]. J Hepatol, 2019,70(3): 361-370.
33
Liaw YF, Sung JJ, Chow WC, et al. Lamivudine for patients with chronic hepatitis b and advanced liver disease[J]. N Engl J Med,2004,351(15): 1521-1531.
34
Choi J, Kim HJ, Lee J, et al. Risk of hepatocellular carcinoma in patients treated with entecavir vs tenofovir for chronic hepatitis b: a korean nationwide cohort study[J]. JAMA Oncol,2019,5(1): 30-36.
35
Hou JL, Zhao W, Lee C, et al. Outcomes of long-term treatment of chronic hbv infection with entecavir or other agents from a randomized trial in 24 countries[J]. Clin Gastroenterol Hepatol, 2020,18(2): 457-467.
36
Lee WA, He GX, Eisenberg E, et al. Selective intracellular activation of a novel prodrug of the human immunodeficiency virus reverse transcriptase inhibitor tenofovir leads to preferential distribution and accumulation in lymphatic tissue[J]. Antimicrob Agents Chemother,2005,49(5): 1898-1906.
37
Kim SU, Seo YS, Lee HA, et al. Hepatocellular carcinoma risk steadily persists over time despite long-term antiviral therapy for hepatitis b: a multicenter study[J]. Cancer Epidemiol Biomarkers Prev,2020,29(4): 832-837.
38
Liang KH, Hsu CW, Chang ML, et al. Peginterferon is superior to nucleos(t)ide analogues for prevention of hepatocellular carcinoma in chronic hepatitis b[J]. J Infect Dis,2016,213(6): 966-974.
39
Ren P, Cao Z, Mo R, et al. Interferon-based treatment is superior to nucleos(t)ide analog in reducing hbv-related hepatocellular carcinoma for chronic hepatitis b patients at high risk[J]. Expert Opin Biol Ther,2018,18(10): 1085-1094.
40
龚文锋,陆世东,钟鉴宏,等. 术前抗病毒治疗对HBV-DNA阴性肝细胞癌患者术后病毒再激活及肝功能的影响[J]. 中国肿瘤临床,2016,43(15): 668-673.
41
Chong CC, Wong GL, Lai PB. Impact of antiviral therapy on post-hepatectomy outcome for hepatitis b-related hepatocellular carcinoma[J]. World J Gastroenterol,2014,20(20): 6006-6012.
42
Heimbach JK, Kulik LM, Finn RS, et al. AAsld guidelines for the treatment of hepatocellular carcinoma[J]. Hepatology,2018,67(1): 358-380.
43
Huang G, Lai EC, Lau WY, et al. Posthepatectomy hbv reactivation in hepatitis b-related hepatocellular carcinoma influences postoperative survival in patients with preoperative low hbv-dna levels[J]. Ann Surg,2013,257(3): 490-505.
44
Wang Z, Duan Y, Zhang J, et al. Preoperative antiviral therapy and microvascular invasion in hepatitis b virus-related hepatocellular carcinoma: a meta-analysis[J]. Eur J Pharmacol, 2020,883(5): 173382-173382.
45
Sohn W, Paik YH, Kim JM, et al. Hbv dna and hbsag levels as risk predictors of early and late recurrence after curative resection of hbv-related hepatocellular carcinoma[J]. Ann Surg Oncol, 2014,21(7): 2429-2435.
46
Bozza C, Cinausero M, Iacono D, et al. Hepatitis b and cancer: a practical guide for the oncologist[J]. Crit Rev Oncol Hematol,2016,98(5): 137-146.
47
Huang YH, Hsiao LT, Hong YC, et al. Randomized controlled trial of entecavir prophylaxis for rituximab-associated hepatitis b virus reactivation in patients with lymphoma and resolved hepatitis b[J]. J Clin Oncol,2013,31(22): 2765-2772.
48
Wu CY, Chen YJ, Ho HJ, et al. Association between nucleoside analogues and risk of hepatitis b virus-related hepatocellular carcinoma recurrence following liver resection[J]. Jama,2012,308(18): 1906-1914.
49
Qi W, Zhang Q, Xu Y, et al. Peg-interferon and nucleos(t)ide analogue combination at inception of antiviral therapy improves both anti-hbv efficacy and long-term survival among hbv dna-positive hepatocellular carcinoma patients after hepatectomy/ablation[J]. J Viral Hepat, 2020,27(4): 387-396.
50
Sarin SK, Kumar M, Lau GK, et al. Asian-pacific clinical practice guidelines on the management of hepatitis b: a 2015 update[J]. Hepatol Int,2016,10(1): 1-98.
51
Jeng WJ, Chen YC, Chien RN, et al. Incidence and predictors of hepatitis b surface antigen seroclearance after cessation of nucleos(t)ide analogue therapy in hepatitis b e antigen-negative chronic hepatitis b[J]. Hepatology,2018,68(2): 425-434.
52
Hadziyannis SJ, Sevastianos V, Rapti I, et al. Sustained responses and loss of hbsag in hbeag-negative patients with chronic hepatitis b who stop long-term treatment with adefovir[J]. Gastroenterology,2012,143(3): 629-636.
53
Chen CH, Hung CH, Wang JH, t al. Long-term incidence and predictors of hepatitis b surface antigen loss after discontinuing nucleoside analogues in noncirrhotic chronic hepatitis b patients[J]. Clin Microbiol Infect,2018,24(9): 997-1003.
54
Liu F, Liu ZR, Li T, et al. Varying 10-year off-treatment responses to nucleos(t)ide analogues in patients with chronic hepatitis b according to their pretreatment hepatitis b e antigen status[J]. J Dig Dis,2018,19(9): 561-571.
55
Wong JS, Wong GL, Tsoi KK, et al. Meta-analysis: the efficacy of anti-viral therapy in prevention of recurrence after curative treatment of chronic hepatitis b-related hepatocellular carcinoma[J]. Aliment Pharmacol Ther,2011,33(10): 1104-1112.
56
Della Corte C, Nobili V, Comparcola D, et al. Management of chronic hepatitis b in children: an unresolved issue[J]. J Gastroenterol Hepatol,2014,29(5): 912-919.
57
张文宏,张大志,窦晓光,等. 聚乙二醇干扰素α治疗慢性乙型肝炎专家共识[J]. 中华肝脏病杂志,2017,25(9): 678-686.
58
Dong Y, Li M, Zhu S, et al. De novo combination antiviral therapy in e antigen-negative chronic hepatitis B virus-infected paediatric patients with advanced fibrosis[J]. J Viral Hepat, 2020,27: 1338-1343.
59
Konopnicki D, Mocroft A, Wit S, et al. Hepatitis b and hiv: prevalence, aids progression, response to highly active antiretroviral therapy and increased mortality in the eurosida cohort[J]. Aids,2005,19(6): 593-601.
60
Thio CL. Hepatitis b and human immunodeficiency virus coinfection[J]. Hepatology, 2009,49(5): 138-145.
61
Thio CL, Seaberg EC, Skolasky RJ, et al. Hiv-1, hepatitis b virus, and risk of liver-related mortality in the multicenter cohort study (MACS)[J]. Lancet,2002,360(9349): 1921-1926.
62
Maponga TG, Glashoff RH, Vermeulen H, et al. Hepatitis b virus-associated hepatocellular carcinoma in south africa in the era of hiv[J]. BMC Gastroenterol,2020,20(1): 226-226.
63
Wandeler G, Mauron E, Atkinson A, et al. Incidence of hepatocellular carcinoma in hiv/hbv-coinfected patients on tenofovir therapy: relevance for screening strategies[J]. J Hepatol, 2019,71(2): 274-280.
64
Liu WR, Tian MX, Jin L, et al. High levels of hepatitis b surface antigen are associated with poorer survival and early recurrence of hepatocellular carcinoma in patients with low hepatitis b viral loads[J]. Ann Surg Oncol,2015,22(3): 843-850.
65
肝细胞癌抗病毒治疗专家组,吴孟超,汤钊猷,等. HBV/HCV相关性肝细胞癌抗病毒治疗专家共识[J]. 实用肝脏病杂志,2014,17(4): 1-6.
66
Katz LH, Paul M, Guy DG, et al. Prevention of recurrent hepatitis b virus infection after liver transplantation: hepatitis b immunoglobulin, antiviral drugs, or both. systematic review and meta-analysis[J]. Transpl Infect Dis,2010,12(4): 292-308.
67
Fox AN, Terrault NA. The option of hbig-free prophylaxis against recurrent hbv[J]. J Hepatol, 2012,56(5): 1189-1197.
68
申川. 中国肝移植术后原发病复发诊疗规范(2019版)[J/CD]. 中华移植杂志(电子版), 2019, 13(4): 21-25.
69
Nasir M, Wu GY. Prevention of hbv recurrence after liver transplant: a review[J]. J Clin Transl Hepatol,2020,8(2): 150-160.
No related articles found!
阅读次数
全文


摘要